Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Dorothea Anrather
LAB HEAD: Thomas A. Leonard
PROVIDER: PXD031827 | Pride | 2022-05-20
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 11 |
Levina Aleksandra A Fleming Kaelin D KD Burke John E JE Leonard Thomas A TA
Nature communications 20220406 1
3-phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a 'master' kinase due to its ability to activate at least 23 downstream protein kinases implicated in various signaling pathways. In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP<sub>3</sub>-mediated face- ...[more]