Dataset Information

Effect of low levels of fluoride in the islets of NOD mice: integrative morphological, immunohistochemical and proteomic analyses

ABSTRACT: Fluoride (F) is used in dentistry, in therapeutic doses, to prevent dental caries. Recently, animal studies have suggested that in low doses, F might reduce glucose and be beneficial in the prophylaxis of diabetes, but the involved mechanisms are still unknown. The present study evaluated changes in the pancreatic islets of NOD mice exposed to low dose of F, using morphological, immunohistochemical and proteomic tools.

INSTRUMENT(S): Xevo G2 Tof, nanoACQUITY UPLC

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Islet

SUBMITTER: Juliana Trevizol

LAB HEAD: Juliana Trevizol

PROVIDER: PXD031865 | Pride | 2023-07-20

REPOSITORIES: Pride

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Metabolic effect of low fluoride levels in the islets of NOD mice: integrative morphological, immunohistochemical, and proteomic analyses.

Trevizol Juliana Sanches JS Dionizio Aline A Delgado Aislan Quintiliano AQ Ventura Talita Mendes Oliveira TMO Ribeiro Caroline Fernanda da Silva CFDS Ribeiro Laura L Buzalaf Nathalia Rabelo NR Cestari Tânia Mary TM Magalhães Ana Carolina AC Suzuki Maiko M Bosqueiro José Roberto JR Buzalaf Marília Afonso Rabelo MAR

Journal of applied oral science : revista FOB 20230605

<h4>Objectives</h4>Fluoride (F) has been widely used to control dental caries, and studies suggest beneficial effects against diabetes when a low dose of F is added to the drinking water (10 mgF/L). This study evaluated metabolic changes in pancreatic islets of NOD mice exposed to low doses of F and the main pathways altered by the treatment.<h4>Methodology</h4>In total, 42 female NOD mice were randomly divided into two groups, considering the concentration of F administered in the drinking wate ...[more]

PMID: 37283331

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