Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Metabolomics of Oral Biofilms exposed to Arginine and Fluoride

ABSTRACT: The study aims to use global metabolomics to investigate: (1) the metabolic profile of supragingival dental plaque from adults with different caries-status and from specific healthy and carious tooth-sites; and (2) the metabolic changes occurring in response to the use of the arginine or fluoride toothpastes for 12 weeks.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Plaque Samples

SUBMITTER: Marcelle Nascimento

PROVIDER: ST000583 | MetabolomicsWorkbench | Thu Jan 12 00:00:00 GMT 2017

REPOSITORIES: MetabolomicsWorkbench

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	mwtab	Other

Items per page:

1 - 1 of 1

Similar Datasets

Homo sapiens oral sample

Project description:Functional changes in the oral microbiome after use of fluoride and arginine dentifrices: a metagenomic and metatranscriptomic study

| PRJNA712952 | ENA

human oral metagenome

Project description:arginine project Oral bacteria Raw sequence reads

| PRJNA339212 | ENA

Dynamic partitioning of branched-chain amino acids- derived nitrogen supports renal cancer progression

Project description:Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related clear cell renal cancer cells (ccRCC) grown in physiological media to identify key stage-specific metabolic vulnerabilities. We show that a VHL loss-dependent reprogramming of branched-chain amino acid catabolism sustains the de novo biosynthesis of aspartate and arginine enabling tumor cells with the flexibility of partitioning the nitrogen of the amino acids depending on their needs. Importantly, we identify the epigenetic reactivation of argininosuccinate synthase (ASS1), a urea cycle enzyme suppressed in primary ccRCC, as a crucial event for metastatic renal cancer cells to acquire the capability to generate arginine, invade in vitro and metastasize in vivo. Overall, our study uncovers a mechanism of metabolic flexibility occurring during ccRCC progression, paving the way for the development of novel stage-specific therapies.

2022-11-10 | GSE217211 | GEO

human oral metagenome

Project description:Tongue Coat Metagenome of Chinese Adults

| PRJNA283472 | ENA

human oral metagenome

Project description:Oral microbiota of 37 Japanese adults

| PRJDB11578 | ENA

Arginine reprograms metabolism in liver cancer via RBM39 [AA_overexpression/RBM39depletion]

Project description:Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are poorly understood. Here, we report that arginine levels are elevated in hepatocellular carcinoma (HCC) despite reduced expression of arginine synthesis genes, in murine and patient tumors. Tumor cells accumulate high levels of arginine due to increased uptake and reduced arginine-to-polyamine conversion. Importantly, the high levels of arginine promote tumor formation via further metabolic reprogramming, including changes in glucose, amino acid, nucleotide, and fatty acid metabolism. Mechanistically, arginine binds RNA-binding motif protein 39 (RBM39) to control expression of metabolic genes. RBM39-mediated upregulation of asparagine synthesis leads to enhanced arginine uptake, creating a positive feedback loop to sustain high arginine levels and oncogenic metabolism. Thus, arginine is a second messenger-like molecule that reprograms metabolism to promote tumor growth.

2023-12-24 | GSE227106 | GEO

Quantification of totalRNA expression in oral squamous cell carcinoma(OSCC)

Project description:Microarrays were used to compare the expression of oral squamous cell carcinoma in the high and low serum IL-6 groups. The results of the analysis may also be used to understand the disease, such as whether patients with high serum IL-6 levels have a poor prognosis or nutritional and metabolic activity status.

2024-01-31 | GSE254525 | GEO

Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity [AbdomFat]

Project description:Some people with obesity are resistant to the adverse metabolic effects of excess adiposity and are considered to have “metabolically healthy obesity” (MHO). However, the mechanisms responsible for MHO are not clear. We performed comprehensive cardiometabolic profiling in 20 adults with MHO (defined by features of normal insulin sensitivity), 20 age-, sex-, and BMI-matched adults with metabolically unhealthy obesity (MUO), and 15 adults who were metabolically healthy and lean (MHL). More than 120 variables were evaluated, including body composition, beta-cell function, 24-hour plasma metabolic profile, rates of de novo lipogenesis and cholesterol synthesis, plasma adipokine concentrations, oxidative stress, plasma lipoprotein profiles, cardiovascular structure/function, skeletal muscle bioactive lipids, and both adipose tissue and skeletal muscle transcriptomics. Using dimensionality reduction approaches, measures of insulinemia and skeletal muscle ceramides were the strongest discriminators of MHO and MUO status. These data clarify the characteristics associated with preserved metabolic health in response to obesity.

2024-03-06 | GSE244118 | GEO

Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity [ThighMuscle]

2024-03-06 | GSE244120 | GEO

human oral metagenome

Project description:Salivary microbiota of jet-lagged 2 adults

| PRJDB5338 | ENA