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Proteomic profiling of capsaicin-induced relapse of chronic colitis

ABSTRACT: It has now been established that consumption of spicy food containing capsaicin is strongly associated with recurrence and worsening of symptoms in IBD.To uncover the potential signaling pathway involved in the capsaicin-induced relapse.To uncover the potential signaling pathway involved in the capsaicin-induced relapse,we performed proteomics of chronic colitis mice following capsaicin administration.Differential expression proteins which were tightly associated with inflammatory pathways have to be revealed.Differential expression proteins which were tightly associated with inflammatory pathways have to be revealed.The proteomic profile can help to identify the crucial pro-inflammatory factor implicated in the procedure of capsaicin-induced disease relapse.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

DISEASE(S): Inflammatory Bowel Disease

SUBMITTER: Kexin Chen

LAB HEAD: Hu Zhang

PROVIDER: PXD032186 | Pride | 2022-06-03

REPOSITORIES: pride

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