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Acute stress induces long-term metabolic, functional and structural remodeling of the heart

ABSTRACT: Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in the long term. Here we explore comprehensively cardiac metabolism, structure and function after a single acute stress. We show that a single pharmacological stress is sufficient to recapitulate the clinical signs of ventricular dysfunction of takotsubo and their apparent reversibility. Interestingly, myocardial glucose metabolic remodeling during the acute phase was also present throughout the late recovery phases. Metabolic stunning where high glucose uptake is derived from glycolysis into alternative non-oxidative pathways such as the hexosamine biosynthetic and polyol pathways parallels with irreversible tissue and vascular remodeling. This study evidences that stress-induced diversion of glucose metabolism is the cause of deleterious structural and functional sequelae in takotsubo hearts.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Heart Failure

SUBMITTER: François GUILLONNEAU

LAB HEAD: Bertrand Tavitian

PROVIDER: PXD032667 | Pride | 2023-06-28

REPOSITORIES: Pride

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			Action	DRS
	BeTA200810_TAKOTSUBO_A10_SCX1_A37783_RJ14_1_1097.d.7z	Other
	BeTA200810_TAKOTSUBO_A10_SCX2_A37784_RJ15_1_1098.d.7z	Other
	BeTA200810_TAKOTSUBO_A10_SCX3_A37785_RJ16_1_1099.d.7z	Other
	BeTA200810_TAKOTSUBO_A10_SCX4_A37786_RJ17_1_1100.d.7z	Other
	BeTA200810_TAKOTSUBO_A10_SCX5_A37787_RJ18_1_1101.d.7z	Other

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Acute stress induces long-term metabolic, functional and structural remodeling of the heart

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