Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Adriana Covarrubias-Pinto
LAB HEAD: Ivan Dikic
PROVIDER: PXD032740 | Pride | 2023-06-19
REPOSITORIES: Pride
Items per page: 1 - 5 of 14 |
Nature 20230524 7964
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy<sup>1</sup>. ER-phagy receptors have a central role in this process<sup>2</sup>, but the regulatory mechanism remains largely unknown. Here we report that ubiquitination of the ER-phagy receptor FAM134B within its reticulon homology domain (RHD) promotes receptor clustering and binding to lipidated LC3B, thereby stimulating ER-phagy. Molecular dynamics (MD) simulations showed how ...[more]