Proteomics

Dataset Information

0

Binding partners of FAM134B WT and 17KR oligomers

ABSTRACT: FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little is known about the molecular and biophysical mechanisms that control and/or switch between these two FAM134B functions.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Adriana Covarrubias-Pinto  

LAB HEAD: Ivan Dikic

PROVIDER: PXD032743 | Pride | 2023-06-19

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20210426_Venus_Empty_01.raw Raw
20210426_Venus_Empty_02.raw Raw
20210426_Venus_Empty_03.raw Raw
20210426_Venus_FAM134B_17KR_control_01.raw Raw
20210426_Venus_FAM134B_17KR_control_02.raw Raw
Items per page:
1 - 5 of 11
altmetric image

Publications

The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy<sup>1</sup>. ER-phagy receptors have a central role in this process<sup>2</sup>, but the regulatory mechanism remains largely unknown. Here we report that ubiquitination of the ER-phagy receptor FAM134B within its reticulon homology domain (RHD) promotes receptor clustering and binding to lipidated LC3B, thereby stimulating ER-phagy. Molecular dynamics (MD) simulations showed how  ...[more]

Similar Datasets

Proteomics FAM134B oligomer ubiquitination and ER-phagy
2023-06-19 | PXD032741 | Pride
Proteomics E3 ligase regulates FAM134B ubiquitination
2023-06-19 | PXD032750 | Pride
Proteomics FAM134B homodimer ubiquitination
2023-06-19 | PXD032740 | Pride
Proteomics Ubiquitination promotes FAM134B-mediated ER-phagy
2023-06-19 | PXD032721 | Pride
Proteomics ARL6IP1 and FAM134B forms a complex
2023-06-19 | PXD032720 | Pride
Proteomics ARL6IP1 is an interacting partner of the ER-phagy receptor FAM134B
2023-06-19 | PXD032718 | Pride
Proteomics E3 ligase AMFR regulates ARL6IP1 Ubiquitination in cells
2023-06-19 | PXD039184 | Pride
Proteomics The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
2023-11-16 | PXD043003 | Pride
Proteomics In vivo FAM134B ubiquitination in AMFR KD cells
2023-06-19 | PXD039187 | Pride
Proteomics In vitro FAM134B ubiquitination
2023-06-19 | PXD039186 | Pride