Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Adriana Covarrubias-Pinto
LAB HEAD: Ivan Dikic
PROVIDER: PXD039187 | Pride | 2023-06-19
REPOSITORIES: pride
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20220826_SFB_EMP_KD_1.raw | Raw | |||
20220826_SFB_EMP_KD_2.raw | Raw | |||
20220826_SFB_EMP_KD_3.raw | Raw | |||
20220826_SFB_EMP_NT_1.raw | Raw | |||
20220826_SFB_EMP_NT_2.raw | Raw |
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Nature 20230524 7964
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy<sup>1</sup>. ER-phagy receptors have a central role in this process<sup>2</sup>, but the regulatory mechanism remains largely unknown. Here we report that ubiquitination of the ER-phagy receptor FAM134B within its reticulon homology domain (RHD) promotes receptor clustering and binding to lipidated LC3B, thereby stimulating ER-phagy. Molecular dynamics (MD) simulations showed how ...[more]