Dataset Information

Quantitative Proteome and Lysine Lactylome of Proteins within Pathological Site of Rotator Cuff Tendinopathy

ABSTRACT: Lysine lactylation (Kla) is a newly discovered posttranslational modification showing the addition of an L-lactate-derived lactyl group to the lysine residue. Histone lactylation has been found to regulate the downstream genes expression involved in the process of infection clearance, homeostasis retore, and tumorigenesis. Like other metabolite mediated PTMs, which the cellular levels of these metabolites affect the stoichiometry of the corresponding PTMs, the level of Kla also responds to the intracellular lactate concentration in a dose-dependent fashion associated with glycolysis metabolism. It has long been noted that manipulation of glycolysis metabolism could affect the tendon cell function, tendon homeostasis, and healing process of tendon.Nonetheless, the lactylation sites and regulations in tendinopathy remain unexplored.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tendon

SUBMITTER: Yuan Lin

LAB HEAD: Pengbin Yin

PROVIDER: PXD033146 | Pride | 2023-05-10

REPOSITORIES: Pride

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Publications

Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.

Lin Yuan Y Chen Ming M Wang Duanyang D Yu Yang Y Chen Ruijing R Zhang Mingming M Yu Haikuan H Huang Xiang X Rao Man M Wang Yezhou Y Li Yi Y Yan Jinglong J Yin Pengbin P

Journal of proteome research 20230509 6

Tendinopathy is a disease with surging prevalence. Lacking understanding of molecular mechanisms impedes the development of therapeutic approaches and agents. Lysine lactylation (Kla) is a newly discovered post-translational modification related to glycolysis. It has long been noted that manipulation of glycolysis metabolism could affect tendon cell function, tendon homeostasis, and healing process of tendon. However, protein lactylation sites in tendinopathy remain unexplored. Here, we conducte ...[more]

PMID: 37159428

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