Proteomics

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Dysregulated proteins in aqueous humor from primary open angle glaucoma patients with clinical correlation

ABSTRACT: Primary open angle glaucoma (POAG) presents as an irreversible optic neuropathy with corresponding visual field deficits and no other notable symptoms. The pathophysiology of POAG remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. This enables us to better understand pathological changes in POAG from a molecular perspective, and may reveal potential diagnostic molecular biomarkers in POAG. We are also interested in correlating differences in AH protein compositions with demographics and clinical severity in POAG patients.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vitreous Humor

DISEASE(S): Open-angle Glaucoma

SUBMITTER: SoFong Cam Ngan  

LAB HEAD: Darren Choy Mun Yoong

PROVIDER: PXD033153 | Pride | 2024-05-23

REPOSITORIES: Pride

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160501_Sun_Jwei_6TMTTTSH_AHPOAG_A_01.raw Raw
160501_Sun_Jwei_6TMTTTSH_AHPOAG_A_02.raw Raw
160501_Sun_Jwei_6TMTTTSH_AHPOAG_A_03.raw Raw
160501_Sun_Jwei_6TMTTTSH_AHPOAG_A_04.raw Raw
160501_Sun_Jwei_6TMTTTSH_AHPOAG_A_05.raw Raw
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Publications

The pathophysiology of Primary Open Angle Glaucoma (POAG) remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. High resolution mass spectrometry-based TMT6plex quantitative proteomics analysis is performed on AH samples collected from POAG patients, and compared against a control group of patients with cataracts. Data are available via ProteomeXchange with i  ...[more]

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