Proteomics

Dataset Information

0

Plasma proteomic signature of major depressive episode in the elderly


ABSTRACT: Depression is a complex and multifactorial disease, affecting about 6.5% of the elderly population in what is referred to as late-life depression (LLD). Despite its public health relevance, there is still limited information about the molecular mechanisms of LLD. We analyzed the blood plasma of 50 older adults through untargeted mass spectrometry and used systems biology tools to identify biochemical pathways and biological processes dysregulated in the disease. We found 96 differentially expressed proteins between LLD patients and control individuals. Using elastic-net regression, we generated a panel of 75 proteins that comprises a potential model for determining the molecular signature of LLD. We also showed that biological pathways related to vesicle-mediated transport and voltage-dependent calcium channels may be dysregulated in LLD. These data can help to build an understanding of the molecular basis of LLD, offering an integrated view of the biomolecular alterations that occur in this disorder.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Blood Cell

DISEASE(S): Major Depressive Disorder

SUBMITTER: Licia C. Silva-Costa  

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD034030 | Pride | 2023-03-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20190405_LCA_CTRL_008.zip Other
20190405_LCA_CTRL_018.zip Other
20190405_LCA_CTRL_023.zip Other
20190405_LCA_CTRL_024.zip Other
20190405_LCA_CTRL_038.zip Other
Items per page:
1 - 5 of 53

Similar Datasets

2018-12-30 | E-MTAB-6304 | biostudies-arrayexpress
2010-05-16 | E-GEOD-14061 | biostudies-arrayexpress
2023-03-11 | PXD032225 | Pride
2014-10-31 | E-MTAB-2738 | biostudies-arrayexpress
2014-10-31 | E-MTAB-2742 | biostudies-arrayexpress
2014-10-31 | E-MTAB-2750 | biostudies-arrayexpress
2014-10-31 | E-MTAB-2748 | biostudies-arrayexpress
2011-04-02 | E-GEOD-28331 | biostudies-arrayexpress
2012-11-29 | E-GEOD-42596 | biostudies-arrayexpress
2022-10-11 | PXD036590 | Pride