Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Blood Serum
SUBMITTER: Xiaojun Liu
LAB HEAD: Xiaojun Liu
PROVIDER: PXD034069 | Pride | 2022-08-11
REPOSITORIES: Pride
Action | DRS | |||
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F9528LQ_KI_serum.raw | Raw | |||
F9528LQ_WT_serum.raw | Raw | |||
Search_result.zip | Other | |||
checksum.txt | Txt |
Items per page: 1 - 4 of 4 |
iScience 20220607 7
Healthy adipose tissue is crucial to maintain normal energy homeostasis. Little is known about the role of murine double minute 2 (MDM2), an E3 ubiquitin ligase and has been highlighted in oncopathology, in adipose tissue. Our results indicated that MDM2 expression was associated with nutritional status. <i>Mdm2</i> adipocyte-specific knock-in (<i>Mdm2</i>-AKI) mice exhibited exacerbated weight gain, insulin resistance, and decreased energy expenditure. Meanwhile, chronic high-fat diet (HFD) exp ...[more]