Proteomics

Dataset Information

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Normalization of adipose oxidative metabolism pathways after bariatric surgery

ABSTRACT: The molecular background of mitochondrial dysfunction in adipose tissue of morbidly obese individuals and bariatric surgery-induced changes in adipose mitochondrial function remain incompletely understood. To evaluate the mechanisms behind the surgery-induced changes and differences between morbidly obese subjects and nonobese controls, we performed a LC-MS/MS proteomics analysis of abdominal subcutaneous (SAT) and visceral adipose tissue samples (VAT) collected from the bariatric surgery, SAT samples collected 6 months after surgery, and control SAT and VAT samples collected from baseline.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Macrophage

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Miikka Honka  

LAB HEAD: Pirjo Nuutila

PROVIDER: PXD034182 | Pride | 2025-01-30

REPOSITORIES: pride

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Dataset's files

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Action DRS
PXD034182_sample_list.xlsx Xlsx
SAT_Sample104_A14_1.raw Raw
SAT_Sample105_A22_1.raw Raw
SAT_Sample10_9_2.raw Raw
SAT_Sample110_20_1.raw Raw
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Publications

Proteomic Profiling Reveals Alterations in Metabolic and Cellular Pathways in Severe Obesity and Following Metabolic Bariatric Surgery.

Dadson Prince P   Honka Miikka-Juhani MJ   Suomi Tomi T   Haridas P A Nidhina PAN   Rokka Anne A   Palani Senthil S   Goltseva Elena E   Wang Ning N   Roivainen Anne A   Salminen Paulina P   James Peter P   Olkkonen Vesa M VM   Elo Laura L LL   Nuutila Pirjo P  

American journal of physiology. Endocrinology and metabolism 20250117

In this study, we investigated the impact of bariatric surgery on the adipose proteome to better understand the metabolic and cellular mechanisms underlying weight loss following the procedure. A total of 46 patients with severe obesity were included, with samples collected both before and after bariatric surgery. Additionally, 15 healthy, non-obese individuals who did not undergo surgery served as controls and were studied once. We utilized quantitative liquid chromatography tandem mass spectro  ...[more]

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