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The Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Serum proteomics

ABSTRACT: To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic states.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Obesity

SUBMITTER: David Potesil

LAB HEAD: Zbynek Zdrahal

PROVIDER: PXD041750 | Pride | 2024-05-24

REPOSITORIES: Pride

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			Action	DRS
	4734_TIMS1_2col-74m_01_01_Slot1-10_1_4924.d.zip	Other
	4734_TIMS1_2col-74m_02_01_Slot1-11_1_4963.d.zip	Other
	4734_TIMS1_2col-74m_03_01_Slot1-12_1_4899.d.zip	Other
	4734_TIMS1_2col-74m_04_01_Slot1-13_1_4969.d.zip	Other
	4734_TIMS1_2col-74m_05_01_Slot1-14_1_4948.d.zip	Other

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Publications

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers.

Hruska Pavel P Kucera Jan J Kuruczova Daniela D Buzga Marek M Pekar Matej M Holeczy Pavol P Potesil David D Zdrahal Zbynek Z Bienertova-Vasku Julie J

American journal of physiology. Endocrinology and metabolism 20231004 5

In this study, we aimed to comprehensively characterize the proteomic landscapes of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in patients with severe obesity, to establish their associations with clinical characteristics, and to identify potential serum protein biomarkers indicative of tissue-specific alterations or metabolic states. We conducted a cross-sectional analysis of 32 patients with severe obesity (16 males and 16 females) of Central European descent who under ...[more]

PMID: 37792298

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The Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Adipose tissue proteomics

Project description:To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic states.

2023-10-16 | PXD041721 | Pride

Enhancement of Tryptic Peptide Signals from Tissue Sections using MALDI IMS Post-ionization (MALDI-2)

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2021-12-30 | PXD023877 | Pride

Microarray for transcript expression comparison of normal and Sox18 dominant negative dermal spheres.

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MOI analysis of purslane responses to salinity stress - leaf

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2023-06-01 | PXD041627 | Pride

Comparative proteomics of human visceral and subcutaneous adipocytes

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