Dataset Information

Plasmodium sporozoites require the protein B9 to invade hepatocytes

ABSTRACT: Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human) Plasmodium Berghei

DISEASE(S): Malaria

SUBMITTER: Soumia HAMADA

LAB HEAD: Solenne Chardonnet

PROVIDER: PXD034830 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	200122_ProteoPB_1DE11_IP-B9_Slot1-8_1_779.d.zip	Other
	200122_ProteoPB_1DE11_IP-B9_Slot1-8_1_779_DA5-2-216.mgf	Mgf
	200122_ProteoPB_1DE11_IP-B9_Slot1-8_1_779_DA5-2-216.xml	Xml
	200122_ProteoPB_1DE11_IP-GFP_Slot1-9_1_783.d.zip	Other
	200122_ProteoPB_1DE11_IP-GFP_Slot1-9_1_783_DA5-2-216.mgf	Mgf

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Publications

<i>Plasmodium</i> sporozoites require the protein B9 to invade hepatocytes.

Fernandes Priyanka P Loubens Manon M Marinach Carine C Coppée Romain R Baron Ludivine L Grand Morgane M Andre Thanh-Phuc TP Hamada Soumia S Langlois Anne-Claire AC Briquet Sylvie S Bun Philippe P Silvie Olivier O

iScience 20230125 2

<i>Plasmodium</i> sporozoites are transmitted to a mammalian host during blood feeding by an infected mosquito and invade hepatocytes for initial replication of the parasite into thousands of erythrocyte-invasive merozoites. Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes. The N-terminus of B9 forms a beta-propeller domain structurally related to CyRPA, a cysteine-r ...[more]

PMID: 36761022

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