Proteomics

Dataset Information

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Proteomic analysis of Dscc1 knockout mouse cells


ABSTRACT: In this project we aimed to explore the effect of Dscc1 gene loss on the proteome. Embyros from wildtype and aged matched Dssc1 null embryos were profiled.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryo, Embryonic Stem Cell

SUBMITTER: James Wright  

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD034902 | Pride | 2023-11-17

REPOSITORIES: Pride

Dataset's files

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Publications

Genetic determinants of micronucleus formation in vivo.

Adams D J DJ   Barlas B B   McIntyre R E RE   Salguero I I   van der Weyden L L   Barros A A   Vicente J R JR   Karimpour N N   Haider A A   Ranzani M M   Turner G G   Thompson N A NA   Harle V V   Olvera-León R R   Robles-Espinoza C D CD   Speak A O AO   Geisler N N   Weninger W J WJ   Geyer S H SH   Hewinson J J   Karp N A NA   Fu B B   Yang F F   Kozik Z Z   Choudhary J J   Yu L L   van Ruiten M S MS   Rowland B D BD   Lelliott C J CJ   Del Castillo Velasco-Herrera M M   Verstraten R R   Bruckner L L   Henssen A G AG   Rooimans M A MA   de Lange J J   Mohun T J TJ   Arends M J MJ   Kentistou K A KA   Coelho P A PA   Zhao Y Y   Zecchini H H   Perry J R B JRB   Jackson S P SP   Balmus G G  

Nature 20240214 8002


Genomic instability arising from defective responses to DNA damage<sup>1</sup> or mitotic chromosomal imbalances<sup>2</sup> can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and diseases associated with genomic instability, the catalogue of genetic players that regulate the generation of MN remains to be determined. Here we analyse 997 mouse mutant lines, revealing 145 genes whose loss significantly increases (  ...[more]

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