Proteomics

Dataset Information

0

Data in support of Temporal changes of inflammation and endothelial dysfunction in multiple sclerosis related to the evolution of enhancing lesions on frequent brain MRI

ABSTRACT: Blood-brain-barrier (BBB) breakdown and active inflammation by relapsing–remitting (RRMS) lesions are hallmarks of multiple sclerosis (MS). Leaky endothelial junctions causes an increased expression of circulating immune cells with associated adhesion molecules on endothelial cell membrane but also an increased production of endothelial derived extracellular microvesicles (EV). Methods: Relapsing–remitting MS (RRMS) patients with no disease-modifying treatment were monitored with weekly intervals using high-resolution 3T MRI scanning. Plasma samples from each measurement were analyzed for protein biomarkers of inflammation by quantitative proteomics, cytokines and chemokines using multiplex immunoassay. Extracellular microvesicles were characterized by an optimized endothelial stress EV Array analysis for detection of soluble secreted microvesicles.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Multiple Sclerosis

SUBMITTER: Allan Stensballe  

LAB HEAD: Allan Stensballe

PROVIDER: PXD035422 | Pride | 2024-01-26

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
1765_DDA.raw Raw
1778_DDA.raw Raw
1788_DDA.raw Raw
1798_DDA.raw Raw
1807_DDA.raw Raw
Items per page:
1 - 5 of 49
altmetric image

Publications

New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis.

Illes Zsolt Z   Jørgensen Malene Møller MM   Bæk Rikke R   Bente Lisa-Marie LM   Lauridsen Jørgen T JT   Hyrlov Kirsten H KH   Aboo Christopher C   Baumbach Jan J   Kacprowski Tim T   Cotton Francois F   Guttmann Charles R G CRG   Stensballe Allan A  

Biomedicines 20231128 12

<h4>Background</h4>Blood-barrier (BBB) breakdown and active inflammation are hallmarks of relapsing multiple sclerosis (RMS), but the molecular events contributing to the development of new lesions are not well explored. Leaky endothelial junctions are associated with increased production of endothelial-derived extracellular microvesicles (EVs) and result in the entry of circulating immune cells into the brain. MRI with intravenous gadolinium (Gd) can visualize acute blood-barrier disruption as  ...[more]

Similar Datasets

Transcriptomics Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis
2023-04-14 | GSE227954 | GEO
Transcriptomics Defective structural RNA processing in relapsing-remitting multiple sclerosis
2015-03-10 | E-GEOD-66573 | biostudies-arrayexpress
Proteomics Multiple sclerosis biomarker discovery in cerebrospinal fluid using glycopeptide enrichment, TMT labeling and LC-MS/MS
2016-10-13 | PXD004540 | Pride
Proteomics Protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
2022-08-01 | PXD028702 | Pride
Transcriptomics Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis
2015-10-06 | GSE73608 | GEO
Transcriptomics Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD56+ cells, exon level]
2016-05-20 | GSE81611 | GEO
Transcriptomics Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD4+ cells, gene level]
2015-09-19 | GSE73079 | GEO
Transcriptomics Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD8+ cells, exon level]
2015-09-19 | GSE73172 | GEO
Transcriptomics Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD8+ cells, gene level]
2015-09-19 | GSE73081 | GEO
Transcriptomics Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD19+ cells, exon level]
2016-05-20 | GSE81606 | GEO