Dataset Information

LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells

ABSTRACT: LC-MS/MS combined with the ChIRP for the mESCs of WT and lncRNA-Smad7 KO

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Stem Cell, Cell Culture

SUBMITTER: Xiaohui Kong

LAB HEAD: Qiaoran Xi

PROVIDER: PXD036394 | Pride | 2023-03-10

REPOSITORIES: Pride

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Publications

LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells.

Kong Xiaohui X Yan Kun K Deng Pujuan P Fu Haipeng H Sun Hongyao H Huang Wenze W Jiang Shuangying S Dai Junbiao J Zhang Qiangfeng Cliff QC Liu Jun-Jie Gogo JG Xi Qiaoran Q

Nucleic acids research 20221001 18

Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and cross-talk between these two branches of developmental signaling is currently the subject of intense research focus. Here, we show that the Nodal induced lncRNA-Smad7 regulates cell fate determination via repression of BMP signaling in mouse embryonic s ...[more]

PMID: 36134711

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			Action	DRS
	ChIRP_MS_rep1.xlsx	Xlsx
	ChIRP_MS_rep1_KO1.raw	Raw
	ChIRP_MS_rep1_KO2.raw	Raw
	ChIRP_MS_rep1_WT1.raw	Raw
	ChIRP_MS_rep1_WT2.raw	Raw