Dataset Information

Urinary proteome related to coronary artery disease and aortic stenosis

ABSTRACT: Coronary artery disease (CAD) and the frequently coexisting aortic valve stenosis (AS) are the heart diseases accounting for the highest proportion of cardiac surgeries. Routine biomarkers for an earl detection of either of these atherosclerotic-rooted conditions would be important to anticipate the diagnosis and to evaluate their severity with imaging techniques before they become advanced to the point where intervention or surgery have limited therapeutic benefit. Urine is an attractive biofluid for biomarker assessment, provided the noninvasive nature of its collection. Therefore, we conducted a shotgun proteomics analysis of urine collected from 12 CAD and/or AS patients and 11 cardiovascular disease-free controls, aiming at identification of putative molecular candidates that could differentiate these diseases from healthy subjects

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Acyrthosiphon Pisum (pea Aphid) Homo Sapiens (human)

TISSUE(S): Urine

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Antje Dittmann

LAB HEAD: Rui Vitorino

PROVIDER: PXD036800 | Pride | 2022-12-18

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20210430_002_S291113_CNT876_Control.raw	Raw
	20210430_003_S291106_CAD52_CAD.raw	Raw
	20210430_005_S291103_CAD28_CAD.raw	Raw
	20210430_008_S291100_AC432_AC.raw	Raw
	20210430_010_S291097_AC316_AC.raw	Raw

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Publications

Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study.

Perpétuo Luís L Barros António S AS Dalsuco Jéssica J Nogueira-Ferreira Rita R Resende-Gonçalves Pedro P Falcão-Pires Inês I Ferreira Rita R Ferreira Rita R Leite-Moreira Adelino A Trindade Fábio F Vitorino Rui R

International journal of molecular sciences 20221105 21

Coronary artery disease (CAD) and the frequently coexisting aortic valve stenosis (AVS) are heart diseases accounting for most cardiac surgeries. These share many risk factors, such as age, diabetes, hypertension, or obesity, and similar pathogenesis, including endothelial disruption, lipid and immune cell infiltration, inflammation, fibrosis, and calcification. Unsuspected CAD and AVS are sometimes detected opportunistically through echocardiography, coronary angiography, and magnetic resonance ...[more]

PMID: 36362368

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