Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stem Cell, Cell Culture
SUBMITTER: Maarten Dhaenens
LAB HEAD: Maarten Dhaenens
PROVIDER: PXD037954 | Pride | 2022-12-03
REPOSITORIES: Pride
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20221122
Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression and cell identity, surface topography can control cell phenotype. This study provides fundamental insights into how surface topography influences nuclear morphology, histone modifications, and expression of histone-associated proteins through advanced histone mass spectrometry and microarray analysis. The authors find that nuclear confinement is associated with ...[more]