Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Fibroblast
SUBMITTER: Robert Liefke
LAB HEAD: Robert Liefke
PROVIDER: PXD038414 | Pride | 2023-06-27
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Evidence.txt | Txt | |||
Groups.txt | Txt | |||
Ref2608_RL_01_20191031.raw | Raw | |||
Ref2608_RL_02_20191031.raw | Raw | |||
Ref2608_RL_03_20191031.raw | Raw |
Items per page: 1 - 5 of 28 |
Cell chemical biology 20230623 7
Inhibition of protein-protein interactions (PPIs) via designed peptides is an effective strategy to perturb their biological functions. The Elongin BC heterodimer (ELOB/C) binds to a BC-box motif and is essential for cancer cell growth. Here, we report a peptide that mimics the high-affinity BC-box of the PRC2-associated protein EPOP. This peptide tightly binds to the ELOB/C dimer (k<sub>D</sub> = 0.46 ± 0.02 nM) and blocks the association of ELOB/C with its interaction partners, both in vitro a ...[more]