Dataset Information

Lung Cancer Exosomes Hypoxic v Normoxic

ABSTRACT: Exosomes derived from NSCLC cells under normoxic or hypoxic conditions were compared to identify hypoxic associated enrichment of proteins in exosomes.

INSTRUMENT(S): nanoACQUITY UPLC, LTQ Orbitrap XL ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Richard Lobb

LAB HEAD: Andreas Moller

PROVIDER: PXD038587 | Pride | 2023-03-10

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Exosomes-Hypoxia2-2ug-20140312.raw	Raw
	Exosomes-Hypoxia3-2ug-20140312.raw	Raw
	Exosomes-Hypoxia4-2ug-20140312.raw	Raw
	Exosomes-Hypoxia5-2ug-20140312.raw	Raw
	Exosomes-normoxia2-2ug-20140312.raw	Raw

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Publications

An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer.

Lobb Richard J RJ Visan Kekoolani S KS Wu Li-Ying LY Norris Emma L EL Hastie Marcus L ML Everitt Sarah S Yang Ian A IA Bowman Rayleen V RV Siva Shankar S Larsen Jill E JE Gorman Jeffrey J JJ MacManus Michael M Leimgruber Antoine A Fong Kwun M KM Möller Andreas A

Communications biology 20230118 1

Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide<sup>1</sup>. Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of only 10-20%. Currently, TNM staging is the gold standard for predicting overall survival and selecting optimal initial treatment options for NSCLC patients, including those with curable stages of disease. However, many patients with locoregionally-confined NSCLC relapse and di ...[more]

PMID: 36653467

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