Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Melanocyte, Cell Culture
DISEASE(S): Cutaneous Malignant Melanoma 1,Melanoma
SUBMITTER: Cristian Munteanu
LAB HEAD: Ștefana M. Petrescu
PROVIDER: PXD039318 | Pride | 2023-07-25
REPOSITORIES: Pride
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190530_stdYMD_HPLC_M2M2M6M6.raw | Raw | |||
190613_stdYMD_HPLC_M2.raw | Raw | |||
190613_stdYMD_HPLC_M6_run01.raw | Raw | |||
190613_stdYMD_HPLC_N.raw | Raw | |||
190618_stdYMD_HPLC_M2M6.raw | Raw |
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iScience 20230625 7
The impact of the peptide amino acids side-chain modifications on the immunological recognition has been scarcely explored. We investigate here the effect of methionine oxidation on the antigenicity of the melanoma immunodominant peptide 369-YMDGTMSQV-377 (YMD). Using CD8<sup>+</sup> T cell activation assays, we found that the antigenicity of the sulfoxide form is higher when compared to the YMD peptide. This is consistent with free energy computations performed on HLA-A∗02:01/YMD/TCR complex sh ...[more]