Proteomics

Dataset Information

0

RB383 retinoblastoma cell line secretome


ABSTRACT: The proteins secreted from RB383 retinoblastoma cell line were analyzed by the GeLC-MS/MS approach.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Retinoblastoma

SUBMITTER: Yuzuru Shiio  

LAB HEAD: Yuzuru Shiio

PROVIDER: PXD039516 | Pride | 2024-01-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
160713YS13_C1.raw Raw
160713YS14_C2.raw Raw
160713YS15_C3.raw Raw
160713YS16_C4.raw Raw
160713YS17_C5.raw Raw
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Publications


Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses nitric oxide and enables retinoblastoma growth. We show that coxsackievirus and adenovirus receptor (CXADR) is the cell-surface receptor for SFRP2 in retinoblastoma cells; that CXADR functions as a "dependence receptor," transmitting a growth-inhibitory sign  ...[more]

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