Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Farnusch Kaschani
LAB HEAD: Dr Farnusch Kaschani
PROVIDER: PXD040156 | Pride | 2024-05-24
REPOSITORIES: Pride
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Day Matthew M Tetik Bilal B Parlak Milena M Almeida-Hernández Yasser Y Räschle Markus M Kaschani Farnusch F Siegert Heike H Marko Anika A Sanchez-Garcia Elsa E Kaiser Markus M Barker Isabel A IA Pearl Laurence H LH Oliver Antony W AW Boos Dominik D
Nature communications 20240227 1
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two separate binding surfaces, the first involving a stretch of highly conserved amino acids in the TopBP1-GINI region, the second a surface on TopBP1-BRCT4. The two surfaces bind to opposite ends of the A domain of the GINS s ...[more]