Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Synovial Tissue
SUBMITTER: Farnusch Kaschani
LAB HEAD: Farnusch Kaschani
PROVIDER: PXD047507 | Pride | 2024-05-21
REPOSITORIES: Pride
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Sowislok Andrea A Busch André A Kaschani Farnusch F Kaiser Markus M Jäger Marcus M
Antibiotics (Basel, Switzerland) 20240409 4
Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid proteome of 21 patients undergoing revision surgery for septic (eight cases) or aseptic (thirteen cases) implant failure using LC-MS/MS to identify potential new biomarkers as future diagn ...[more]