Proteomics

Dataset Information

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Proteomic differences in the synovial fluid of patients undergoing septic or aseptic revision arthroplasty


ABSTRACT: In 21 patients undergoing revision arthroplasty due to septic or aseptic implant loosening, synovial fluid was collected intraoperatively after opening the joint capsule. In a proteomic MS approach, we wanted now to investigate these synovial fluids for novel proteogenic markers of periprosthetic infections.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Synovial Tissue

SUBMITTER: Farnusch Kaschani  

LAB HEAD: Farnusch Kaschani

PROVIDER: PXD047507 | Pride | 2024-05-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
ACE_0758_AS01.raw Raw
ACE_0758_AS02.raw Raw
ACE_0758_AS03.raw Raw
ACE_0758_AS04.raw Raw
ACE_0758_AS05.raw Raw
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Publications

Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure.

Sowislok Andrea A   Busch André A   Kaschani Farnusch F   Kaiser Markus M   Jäger Marcus M  

Antibiotics (Basel, Switzerland) 20240409 4


Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid proteome of 21 patients undergoing revision surgery for septic (eight cases) or aseptic (thirteen cases) implant failure using LC-MS/MS to identify potential new biomarkers as future diagn  ...[more]

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