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DIA proteomics on mouse tissue to investigate the GAPDH redox switch

ABSTRACT: The glycolytic enzyme GAPDH is equipped with a redox switch that rapidly and reversibly inactivates the enzyme in the presence of hydrogen peroxide. The physiological implications of the redox switch were investigated in C57BL/6NTac wildtype and GAPDH(T175A) knock-in mice generated by CRISPR/Cas9 genome editing.

INSTRUMENT(S): timsTOF Pro 2

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Kidney

SUBMITTER: Justus L. Großmann

LAB HEAD: Markus Ralser

PROVIDER: PXD040620 | Pride | 2023-04-10

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20220518_Mouse-RefProteome_UP000000589_10090.fasta	Fasta
	20220804_PRO2_LS_02_60-0062_kidney_pool_A1_S1-C1_1_3592.d.Zip	Other
	20220804_PRO2_LS_03_60-0062_kidney_1_A2_S1-A2_1_3593.d.Zip	Other
	20220804_PRO2_LS_04_60-0062_kidney_2_B2_S1-B2_1_3594.d.Zip	Other
	20220804_PRO2_LS_05_60-0062_kidney_3_C2_S1-C2_1_3595.d.Zip	Other

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