Proteomics

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Smooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate

ABSTRACT: Cigarette smoke is a risk factor for inflammatory diseases, such as atherosclerosis. Tobacco smoke interacts with inflammatory cytokines to produce endothelial dysfunction and induces pro-inflammatory and pro-atherosclerotic effects in vascular tissue. Smooth muscle cells (SMCs) are present in the media of human arteries, and are considered protective against atherosclerotic plaque destabilization. Contractile SMCs are the most prominent cell type in the healthy vessel wall. SMCs are not terminally differentiated, and retain the ability to undergo a phenotypic switch from a contractile to a dedifferentiated synthetic state to express inflammatory markers and a phagocytic activity in response to environmental cues. The aim of our study was to evaluate the effects in human SMCs of lipophilic component from cigarette smoke condensate (CSC) and of hydrophilic components of Electronic-cigarette, Tobacco heating products, or cigarette smoke.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Aorta Smooth Muscle Cell Line

SUBMITTER: Stefano Bellosta  

LAB HEAD: Stefano Bellosta

PROVIDER: PXD041174 | Pride | 2023-05-10

REPOSITORIES: Pride

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Publications

Smooth Muscle Cell Phenotypic Switch Induced by Traditional Cigarette Smoke Condensate: A Holistic Overview.

Bianchi Laura L   Damiani Isabella I   Castiglioni Silvia S   Carleo Alfonso A   De Salvo Rossana R   Rossi Clara C   Corsini Alberto A   Bellosta Stefano S  

International journal of molecular sciences 20230329 7

Cigarette smoke (CS) is a risk factor for inflammatory diseases, such as atherosclerosis. CS condensate (CSC) contains lipophilic components that may represent a systemic cardiac risk factor. To better understand CSC effects, we incubated mouse and human aortic smooth muscle cells (SMCs) with CSC. We evaluated specific markers for contractile [i.e., actin, aortic smooth muscle (<i>ACTA2</i>), calponin-1 (<i>CNN1</i>), the Kruppel-like factor 4 (<i>KLF4</i>), and myocardin (<i>MYOCD</i>) genes] a  ...[more]

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