Proteomics

Dataset Information

0

A novel peptide from Bothrops cotiara peptidome

ABSTRACT: The knowledge regarding toxins diversity, composition, structure, molecular and pharmacological interactions involved in the process of envenomation provide lessons for drug design based on these natural molecular scaffolds and pharmacophores of toxins. This study unravels new toxins sequenced by mass spectrometry analysis of Bothrops cotiara peptidome, and the potential biological activities of these toxins were explored.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Bothrops Cotiara

TISSUE(S): Venom

SUBMITTER: Alexandre Keiji Tashima  

LAB HEAD: Alexandre Keiji Tashima

PROVIDER: PXD041473 | Pride | 2023-10-20

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20201126_Bc7a_250ng_5-35_60min.mzML Mzml
20201126_Bc7a_250ng_5-35_60min.raw.zip Raw
20201126_Bc7a_2p5ug_5-35_60min.mzML Mzml
20201126_Bc7a_2p5ug_5-35_60min.raw.zip Raw
20201128_Bc7a_2p5ng_5-35_60min.mzML Mzml
Items per page:
1 - 5 of 18
altmetric image

Publications

Snake venoms are primarily composed of proteins and peptides, which selectively interact with specific molecular targets, disrupting prey homeostasis. Identifying toxins and the mechanisms involved in envenoming can lead to the discovery of new drugs based on natural peptide scaffolds. In this study, we used mass spectrometry-based peptidomics to sequence 197 peptides in the venom of Bothrops cotiara, including a novel 7-residue peptide derived from a snake venom metalloproteinase. This peptide,  ...[more]

Similar Datasets

Proteomics A multi-omics approach unravels new toxins with potential antimicrobial, antiviral and antitumoral activities in the venom of Acanthoscurria rondoniae
2020-07-20 | PXD019343 | Pride
Proteomics Characterization of the gila monster (Heloderma suspectum suspectum) venom proteome
2015-01-26 | PXD001343 | Pride
Proteomics Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins with potential antimicrobial activity
2016-08-02 | PXD003884 | Pride
Transcriptomics De Novo Transcriptome Sequencing for Tetramorium bicarinatum: The first comprehensive venom gland transcriptome analysis from an ant species.
2015-01-08 | E-GEOD-53988 | biostudies-arrayexpress
Proteomics Exploring Top-Down Mass Spectrometric Approaches To Probe Forest Cobra (Naja melanoleuca) Venom Proteoforms
2024-09-05 | PXD052561 | Pride
Proteomics Mass spectrometry of Manica rubida venom
2020-03-20 | PXD015675 | Pride
Proteomics Tetraponera aethiops venom peptidome
2020-01-10 | PXD016337 | Pride
Proteomics Lachesis muta snake venom peptidome
2023-10-23 | PXD045732 | Pride
Transcriptomics De novo assembly of siRNA immunity in wild plants
2012-06-01 | E-GEOD-22079 | biostudies-arrayexpress
Transcriptomics RNA-seq transcriptome analysis of Panax japonicus, and its comparison with other Panax species to identify potential genes involved in the saponins biosynthesis
2016-04-01 | E-GEOD-78893 | biostudies-arrayexpress