Proteomics

Dataset Information

0

Proteomic Analysis of the Urothelial Cancer Landscape


ABSTRACT: SMRD method development, LC-MS/MS evaluation experiment, setup #1, please see publication for details.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urinary Bladder

DISEASE(S): Bladder Transitional Cell Carcinoma

SUBMITTER: Franz Dressler  

LAB HEAD: Franz Friedrich Dressler

PROVIDER: PXD041873 | Pride | 2024-06-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
1.xlsx Xlsx
1_1.wiff Wiff
1_1.wiff.scan Wiff
1_2.wiff Wiff
1_2.wiff.scan Wiff
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Publications


Urothelial bladder cancer (UC) has a wide tumor biological spectrum with challenging prognostic stratification and relevant therapy-associated morbidity. Most molecular classifications relate only indirectly to the therapeutically relevant protein level. We improve the pre-analytics of clinical samples for proteome analyses and characterize a cohort of 434 samples with 242 tumors and 192 paired normal mucosae covering the full range of UC. We evaluate sample-wise tumor specificity and rank bioma  ...[more]

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