Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Andrey Tvardovskiy
LAB HEAD: Till Bartke
PROVIDER: PXD042368 | Pride | 2023-12-10
REPOSITORIES: Pride
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H3K27me3_35bp_repl1.raw | Raw | |||
H3K27me3_35bp_repl2.raw | Raw | |||
H3K27me3_35bp_repl3.raw | Raw | |||
H3K27me3_40bp_repl1.raw | Raw | |||
H3K27me3_40bp_repl2.raw | Raw |
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Nature 20240306 8004
DNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome<sup>1,2</sup>. While many 'readers' of individual modifications have been described<sup>3-5</sup>, how chromatin states comprising composite modification signatures, histone variants and internucleosomal linker DNA are interpreted is a major open question. Here we use a multidimensional proteomics strategy to systematically examine the interaction of around 2,000 nuclear proteins wi ...[more]