Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: Hossein Fazelinia
LAB HEAD: Stuart A. Lipton
PROVIDER: PXD042436 | Pride | 2024-05-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
q170921_SL1236_01.raw | Raw | |||
q170921_SL1236_02.raw | Raw | |||
q170921_SL1236_03.raw | Raw | |||
q170921_SL1236_04.raw | Raw | |||
q170921_SL1236_05.raw | Raw |
Items per page: 1 - 5 of 7 |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20240118 12
In Alzheimer's disease (AD), dysfunctional mitochondrial metabolism is associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced pluripotent stem cell (hiPSC)-derived cerebrocortical neurons (hiN), evidence is found for compromised mitochondrial energy in AD using the Seahorse platform to analyze glycolysis and oxidative phosphorylation ...[more]