Dataset Information

Mouse muscle proteome for sarcopenia study

ABSTRACT: Aging and lack of exercise are ones of most important attributing causes of muscle loss. To find a novel factor contributing to muscle loss, we performed mass spectrometry-based proteomic analysis in gastrocnemii of unloading and old mice compared to those of exercised and young mice.

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fibroblast

DISEASE(S): Disease Free

SUBMITTER: Kyunggon Kim

LAB HEAD: Kyunggon Kim

PROVIDER: PXD043715 | Pride | 2024-08-10

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20170720_Exercise_1st_F01.raw	Raw
	20170720_Exercise_1st_F02.raw	Raw
	20170720_Exercise_1st_F03.raw	Raw
	20170720_Exercise_1st_F04.raw	Raw
	20170720_Exercise_1st_F05.raw	Raw

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Publications

Extracellular C1qbp inhibits myogenesis by suppressing NFATc1.

Kim Jin-Man JM Kim Ho Kyoung HK Cho Han Jin HJ Moon Sung-Ah SA Kim Yewon Y Hong Jeong Yeon JY Lee Seung Hun SH Kim Kyunggon K Koh Jung-Min JM

Scientific reports 20240708 1

Aging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limited skeletal muscles. Mouse gastrocnemius muscles were subjected to mass spectrometry-based proteomic analysis. The muscle proteomes of hindlimb-unloaded and aged mice were compared to those of exercised and young mice, respectively. C1qbp expression was signific ...[more]

PMID: 38977785

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