Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
DISEASE(S): Cardiovascular System Disease,Cardiovascular System
SUBMITTER: Ryan Bia
LAB HEAD: Sarah Franklin
PROVIDER: PXD044236 | Pride | 2023-10-24
REPOSITORIES: Pride
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JCI insight 20230922 18
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intracardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes-induced HFpEF, abnormal remodeling of cardiomyocyte transverse-tubule microdomains occurs with downregulation of the membrane scaffolding protein cardiac bridging integrator 1 (cBIN1). Transduction of cBIN1 by ...[more]