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Mapping the cellular and molecular landscape of cardiac non-myocytes in murine type-2 diabetes

ABSTRACT: Here we define key single-cell transcriptional alterations within cardiac non-myocytes, from ventricles of spontaneously type-2 diabetic (db/db) and control (db/h) mouse hearts ([B6.BKS(D)-Lepr/J], stock #000697). The cell preparation sequenced consisted of metabolically active, live and nucleated non-myocyte cells, which were depleted of endothelial cells. The objective of this experiment was to develop a framework for understanding the dynamics of cardiac cell networks in murine type-2 diabetes, as a resource for future mechanistic studies.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Malathi Dona

PROVIDER: E-MTAB-11940 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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