Dataset Information

Effect of transplantation on human islets

ABSTRACT: To assess the effect of transplantation on human islet signature, we transplanted 500-800 human iselts under the kidney capsule of diabetic mice. The mice were rendered diabetic with allowan. The transplanted islets were collected after 30 days, and compared to non-trasnplanted islets.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Islet

SUBMITTER: Thomas Aga Legøy

LAB HEAD: Simona Chera

PROVIDER: PXD044502 | Pride | 2025-04-03

REPOSITORIES: Pride

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			Action	DRS
	438175_j44274_TOMprm.mzIdentML	Mzid
	438176_j44273_TOMprm.mzIdentML	Mzid
	438177_j44272_TOMprm.mzIdentML	Mzid
	438178_j44271_TOMprm.mzIdentML	Mzid
	438179_j44270_TOMprm.mzIdentML	Mzid

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Publications

Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations.

Mathisen Andreas F AF Abadpour Shadab S Legøy Thomas Aga TA Paulo Joao A JA Ghila Luiza L Scholz Hanne H Chera Simona S

Acta physiologica (Oxford, England) 20230824 2

<h4>Aim</h4>The variation in quality between the human islet samples represents a major problem for research, especially when used as control material. The assays assessing the quality of human islets used in research are non-standardized and limited, with many important parameters not being consistently assessed. High-throughput studies aimed at characterizing the diversity and segregation markers among apparently functionally healthy islet preps are thus a requirement. Here, we designed a pilo ...[more]

PMID: 37621186

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