Dataset Information

Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly

ABSTRACT: Two immunoprecipitation datasets of phage SECphi27 and SECphi4 modified by the Bil defense system. For both phages, control samples with a mutated Bil defense system were run.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Escherichia Phage Secphi4 Escherichia Coli Escherichia Phage Secphi27

SUBMITTER: Jens Hör

LAB HEAD: Rotem Sorek

PROVIDER: PXD044622 | Pride | 2024-07-18

REPOSITORIES: Pride

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Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly.

Hör Jens J Wolf Sharon G SG Sorek Rotem R

Nature 20240717 8022

Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence<sup>1-5</sup>. Here we studied an antiphage defence system in bacteria, comprising a ubiquitin-like protein, ubiquitin-conjugating enzymes E1 and E2, and a deubiquitinase. We show that during phage infection, this system specifically conjugates the ubiquitin-like protein to the phage central tail fibre, a protein at the tip of the tail that is essential for tail assembl ...[more]

PMID: 39020165

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			Action	DRS
	MQ_txt.zip	Other
	SECphi27_pulldown.raw	Raw
	SECphi27_pulldown.xlsx	Xlsx
	SECphi27_pulldown_control.raw	Raw
	SECphi27_pulldown_control.xlsx	Xlsx