Dataset Information

De-obstruction of bladder outlet in humans reverses organ remodeling

ABSTRACT: Bladder outlet obstruction (BOO) causes lower urinary tract symptoms and objectifiable urodynamic changes in bladder function. We carried out an integrated transcriptome and proteome analysis of bladder samples from male patients with BOO before and 3 months after de-obstruction surgery (transurethral resection of the prostate, TURP). mRNA and protein profiles were correlated with urodynamic findings, specifically voiding detrusor pressure (PdetQmax) before TURP. Patients with high PdetQmax showed less advanced remodeling and inflammatory changes than those with lower values. We oberved significant dysregulation of gene expression, which was reversed by de-obstruction in both patients’ groups. We propose a series of biomarker genes, indicative of BOO, and possibly contributing to the bladder changes. Our data sheds light on the stages of progressive obstruction-induced bladder decompensation, and might add selecting the operation point to avoid the loss of contractility.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urinary Bladder

SUBMITTER: Manfred Heller

LAB HEAD: Katia Monastyrskaya

PROVIDER: PXD044777 | Pride | 2024-05-21

REPOSITORIES: Pride

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			Action	DRS
	20211115_B23_2_MB_i01.raw	Raw
	20211115_B23_2_MB_i02.raw	Raw
	20211115_B23_2_MB_i03.raw	Raw
	20211115_B23_2_MB_i04.raw	Raw
	20211115_B23_2_MB_i05.raw	Raw

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De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors.

Akshay Akshay A Gheinani Ali Hashemi AH Besic Mustafa M Braga Sophie S Uldry Anne-Christine AC Heller Manfred M Rehrauer Hubert H Fournier Catharine Aquino CA Burkhard Fiona C FC Monastyrskaya Katia K

BMC urology 20240207 1

<h4>Background</h4>Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function. When conservative medical treatments are exhausted, surgical interventions like transurethral resection of the prostate (TURP) are employed for bladder outlet de-obstruction. Elucidating the molecular changes in the human bladder resulting from BPO a ...[more]

PMID: 38326801

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