Proteomics

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Label free proteomic experiment using M395 sensitive and resistance melanoma cultures to targeted therapy

ABSTRACT: In this study, we combined tRNA sequencing, quantitative proteomics and systematic codon usage analysis of translated mRNA to uncover new mechanisms underlying translation reprogramming and therapy resistance in melanoma.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Najla El-Hachem  

LAB HEAD: Dr Pierre CLOSE, Ph.D.

PROVIDER: PXD044863 | Pride | 2024-08-09

REPOSITORIES: Pride

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Experiment_U_Liege_6780_R1_from_MSB32704A.mzid.gz Mzid
Experiment_U_Liege_6780_R1_from_MSB32704A.mzid_Experiment_U_Liege_6780_R1_from_MSB32704A.MGF Mzid
Experiment_U_Liege_6780_R2_from_MSB32705A.mzid.gz Mzid
Experiment_U_Liege_6780_R2_from_MSB32705A.mzid_Experiment_U_Liege_6780_R2_from_MSB32705A.MGF Mzid
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Publications

Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress tumourigenesis. Here we show that valine aminoacyl-tRNA synthetase (VARS) is a key player in the codon-biased translation reprogramming induced by resistance to targeted (MAPK) therapy in melanoma. The proteome rewiring in patient-derived MAPK therapy-resistant melanoma is biased towards the usage of valine and c  ...[more]

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