Proteomics

Dataset Information

0

Label free proteomic experiment using control and VARS-depleted RES M395 melanoma cultures

ABSTRACT: In this study, we combined quantitative proteomics and systematic codon usage analysis of translated mRNA, polysome and ribosome sequencing to uncover VARS translational targets.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Najla El-Hachem  

LAB HEAD: Dr Pierre CLOSE, Ph.D.

PROVIDER: PXD044910 | Pride | 2024-08-09

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Experiment_U._Liege_7592_A1_from_MSB39315A.mzid.gz Mzid
Experiment_U._Liege_7592_A1_from_MSB39315A.mzid_Experiment_U._Liege_7592_A1_from_MSB39315A.MGF Mzid
Experiment_U._Liege_7592_A2_from_MSB39316A.mzid.gz Mzid
Experiment_U._Liege_7592_A2_from_MSB39316A.mzid_Experiment_U._Liege_7592_A2_from_MSB39316A.MGF Mzid
Experiment_U._Liege_7592_A3_from_MSB39317A.mzid.gz Mzid
Items per page:
1 - 5 of 18
altmetric image

Publications

Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress tumourigenesis. Here we show that valine aminoacyl-tRNA synthetase (VARS) is a key player in the codon-biased translation reprogramming induced by resistance to targeted (MAPK) therapy in melanoma. The proteome rewiring in patient-derived MAPK therapy-resistant melanoma is biased towards the usage of valine and c  ...[more]

Similar Datasets

Proteomics Label free proteomic experiment using M395 sensitive and resistance melanoma cultures to targeted therapy
2024-08-09 | PXD044863 | Pride
Proteomics Wobble tRNA modification dependent proteome
2021-02-24 | PXD019620 | Pride
Proteomics Subtyping Lewy body disorders using proteomics
2022-07-20 | PXD034441 | Pride
Genomics Illumina HiSeq next -generation sequencing of telomere fusion amplicons purified from crisis-stage MCR5HPVE6E7 and TALEN-transfected HCT116 cell lines at 48 and 120 hours post-transfection.
2016-02-24 | E-MTAB-3811 | biostudies-arrayexpress
Proteomics Identification of PNPase and RhlB binding proteins in Deinococcus radiodurans
2022-07-09 | PXD028866 | Pride
Proteomics MmoD regulates soluble methane monooxygenase and methanobactin production in Methylosinus trichosporium OB3b
2023-09-29 | PXD045741 | Pride
Proteomics The proteomic of IL-4 treated BMDMs from Wt and Elp3 KO mice
2022-09-12 | PXD033962 | Pride
Proteomics An adaptive biomolecular condensation response is conserved across environmentally divergent species
2024-03-03 | PXD044702 | Pride
Genomics A biophysical DNA binding model for the LEAFY transcription factor reveals the evolutionary fluidity of its binding sites
2011-05-13 | E-GEOD-24568 | biostudies-arrayexpress
Genomics Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution [ChIP-seq]
2015-08-24 | E-GEOD-59942 | biostudies-arrayexpress