Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ziang Lu
LAB HEAD: Xiang Zhou
PROVIDER: PXD045634 | Pride | 2024-05-24
REPOSITORIES: Pride
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G4PID_rep1.raw | Raw | |||
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miniTurbo_rep1.raw | Raw |
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Lu Ziang Z Xie Shengjie S Su Haomiao H Han Shaoqing S Huang Haiyan H Zhou Xiang X
Nucleic acids research 20240401 7
G-quadruplexes (G4s) are noncanonical nucleic acid structures pivotal to cellular processes and disease pathways. Deciphering G4-interacting proteins is imperative for unraveling G4's biological significance. In this study, we developed a G4-targeting biotin ligase named G4PID, meticulously assessing its binding affinity and specificity both in vitro and in vivo. Capitalizing on G4PID, we devised a tailored approach termed G-quadruplex-interacting proteins specific biotin-ligation procedure (PLG ...[more]