Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Retinal Rod Cell, Retinal Rod
SUBMITTER: Tae Jun Lee
LAB HEAD: Rajendra Apte
PROVIDER: PXD045667 | Pride | 2024-06-16
REPOSITORIES: Pride
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17171_ec04372_tc_903_P1_1.mzIdentML | Mzid | |||
17172_ec04373_tc_903_P1_2.mzIdentML | Mzid | |||
17173_ec04374_tc_903_P2.mzIdentML | Mzid | |||
ec04372_tc-903_P1_1.raw | Raw | |||
ec04373_tc-903_P1_2.raw | Raw |
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Lee Tae Jun TJ Sasaki Yo Y Ruzycki Philip A PA Ban Norimitsu N Lin Joseph B JB Wu Hung-Ting HT Santeford Andrea A Apte Rajendra S RS
JCI insight 20240116 4
AMP-activated protein kinase (AMPK) plays a crucial role in maintaining ATP homeostasis in photoreceptor neurons. AMPK is a heterotrimeric protein consisting of α, β, and γ subunits. The independent functions of the 2 isoforms of the catalytic α subunit, PRKAA1 and PRKAA2, are uncharacterized in specialized neurons, such as photoreceptors. Here, we demonstrate in mice that rod photoreceptors lacking PRKAA2, but not PRKAA1, showed altered levels of cGMP, GTP, and ATP, suggesting isoform-specific ...[more]