Proteomics

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Phosphoproteome dynamics during differentiation of SGBS adipocytes

ABSTRACT: Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the human SGBS cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and terminal time point.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Subcutaneous Preadipocyte

DISEASE(S): Simpson-golabi-behmel Syndrome Type 1

SUBMITTER: Alix Sarah Aldehoff  

LAB HEAD: Kristin Schubert

PROVIDER: PXD045770 | Pride | 2024-06-13

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20211020_Uniprot_HomoSapiens_Refset_AA.fasta Fasta
20230126_AA_differentiating_adipocytes_phosphoproteome_SGBS_corrected.mgf Mgf
20230126_AA_differentiating_adipocytes_phosphoproteome_SGBS_corrected.msf Msf
20230126_AA_differentiating_adipocytes_phosphoproteome_SGBS_corrected.mzML Mzml
20230126_AA_differentiating_adipocytes_phosphoproteome_SGBS_corrected.mzid.gz Mzid
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Publications

Obesity, characterized by enlarged and dysfunctional adipose tissue, is among today's most pressing global public health challenges with continuously increasing prevalence. Despite the importance of post-translational protein modifications (PTMs) in cellular signaling, knowledge of their impact on adipogenesis remains limited. Here, we studied the temporal dynamics of transcriptome, proteome, central carbon metabolites, and the acetyl- and phosphoproteome during adipogenesis using LC-MS/MS combi  ...[more]

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