Proteomics

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Phosphoproteome dynamics during differentiation of 3T3-L1 adipocytes

ABSTRACT: Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the murine 3T3-L1 cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and terminal time point.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fibroblast

SUBMITTER: Alix Sarah Aldehoff  

LAB HEAD: Kristin Schubert

PROVIDER: PXD045778 | Pride | 2024-06-13

REPOSITORIES: Pride

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Action DRS
20220524_Uniprot_MusMusculus_Refset_AA.fasta Fasta
20230126_AA_differentiating_adipocytes_phosphoproteome_3T3L1_corrected.mgf Mgf
20230126_AA_differentiating_adipocytes_phosphoproteome_3T3L1_corrected.msf Msf
20230126_AA_differentiating_adipocytes_phosphoproteome_3T3L1_corrected.mzML Mzml
20230126_AA_differentiating_adipocytes_phosphoproteome_3T3L1_corrected.mzid.gz Mzid
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Publications

Obesity, characterized by enlarged and dysfunctional adipose tissue, is among today's most pressing global public health challenges with continuously increasing prevalence. Despite the importance of post-translational protein modifications (PTMs) in cellular signaling, knowledge of their impact on adipogenesis remains limited. Here, we studied the temporal dynamics of transcriptome, proteome, central carbon metabolites, and the acetyl- and phosphoproteome during adipogenesis using LC-MS/MS combi  ...[more]

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