Proteomics

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Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia

ABSTRACT: Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regulating cellular metabolism, but little is known about its role in the form-deprived myopic retina. In this study, we performed lactylation proteomic analysis of the retinas of form-deprived myopic guinea pigs and found downregulated levels of lactylation of metabolism-critical enzymes in the retina. As the first report on retinal lactylation in myopic eyes, this study provides a reliable basis for further studies on retinal lactylation in myopic eyes.

INSTRUMENT(S): timsTOF

ORGANISM(S): Cavia Porcellus (guinea Pig)

TISSUE(S): Retina

DISEASE(S): Myopia

SUBMITTER: jiaojiao Feng  

LAB HEAD: Hongsheng Bi

PROVIDER: PXD046495 | Pride | 2024-10-17

REPOSITORIES: Pride

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Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.

Feng Jiaojiao J   Chen Xiaoniao X   Li Runkuan R   Xie Yunxiao Y   Zhang Xiuyan X   Guo Xiaoxiao X   Zhao Lianghui L   Xu Zhe Z   Song Yifan Y   Song Jike J   Bi Hongsheng H  

iScience 20240729 9

The biological mechanisms underlying the development of myopia have not yet been completely elucidated. The retina is critical for visual signal processing, which primarily utilizes aerobic glycolysis to produce lactate as a metabolic end product. Lactate facilitates lysine lactylation (Kla), a posttranslational modification essential for transcriptional regulation. This study found increased glycolytic flux and lactate accumulation in the retinas of form-deprived myopic guinea pigs. Subsequentl  ...[more]

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