Dataset Information
Off-target profiling of Olaparib using Thermal Proteome Profiling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Uwb1.289 Cell, Cell Line Cell
SUBMITTER: 
Maria Faelth Savitski
LAB HEAD: Marcus Bantscheff
PROVIDER: PXD046614 | Pride | 2024-05-13
REPOSITORIES: pride
Dataset's files
Items per page: 1 - 5 of 143 |
Publications
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.
Molecular systems biology 20240307 4
Complex disease phenotypes often span multiple molecular processes. Functional characterization of these processes can shed light on disease mechanisms and drug effects. Thermal Proteome Profiling (TPP) is a mass-spectrometry (MS) based technique assessing changes in thermal protein stability that can serve as proxies of functional protein changes. These unique insights of TPP can complement those obtained by other omics technologies. Here, we show how TPP can be integrated with phosphoproteomic ...[more]
