Proteomics

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Thermal proteome profiling of ticagrelor in Staphylococcus aureus

ABSTRACT: We performed two dimensional thermal proteome profiling (2D-TPP) of ticagrelor to study its impact in Staphylococcus aureus.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: André Mateus  

LAB HEAD: Athanasios Typas

PROVIDER: PXD036188 | Pride | 2024-01-26

REPOSITORIES: pride

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Bert_S2316_AM_2DTPP_Saureus_wholecell_ticagrelor_T1T2_n1_R2_F1.raw Raw
Bert_S2316_AM_2DTPP_Saureus_wholecell_ticagrelor_T1T2_n1_R2_F2.raw Raw
Bert_S2316_AM_2DTPP_Saureus_wholecell_ticagrelor_T1T2_n1_R2_F3.raw Raw
Bert_S2316_AM_2DTPP_Saureus_wholecell_ticagrelor_T1T2_n1_R2_F4.raw Raw
Bert_S2316_AM_2DTPP_Saureus_wholecell_ticagrelor_T1T2_n1_R2_F5.raw Raw
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Publications

Drug combinations can expand options for antibacterial therapies but have not been systematically tested in Gram-positive species. We profiled ~8,000 combinations of 65 antibacterial drugs against the model species Bacillus subtilis and two prominent pathogens, Staphylococcus aureus and Streptococcus pneumoniae. Thereby, we recapitulated previously known drug interactions, but also identified ten times more novel interactions in the pathogen S. aureus, including 150 synergies. We showed that two  ...[more]

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