Proteomics

Dataset Information

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Thermal proteome profiling of temporal dynamics of infection of SARS-CoV-2

ABSTRACT: We performed two dimensional thermal proteome profiling (2D-TPP) to profile the infection dynamics of SARS-CoV-2 infection in Caco-2 cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Andre Mateus  

LAB HEAD: Mikhail M. Savitski

PROVIDER: PXD022115 | Pride | 2020-11-23

REPOSITORIES: pride

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Dataset's files

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Bert_S2283_AM_JS_2DTPP_infectiontimecourse_Caco2_n1_T1T2_R1_F1.raw Raw
Bert_S2283_AM_JS_2DTPP_infectiontimecourse_Caco2_n1_T1T2_R1_F10.raw Raw
Bert_S2283_AM_JS_2DTPP_infectiontimecourse_Caco2_n1_T1T2_R1_F11.raw Raw
Bert_S2283_AM_JS_2DTPP_infectiontimecourse_Caco2_n1_T1T2_R1_F12.raw Raw
Bert_S2283_AM_JS_2DTPP_infectiontimecourse_Caco2_n1_T1T2_R1_F2.raw Raw
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Publications

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health and has compromised economic stability. In addition to the development of an effective vaccine, it is imperative to understand how SARS-CoV-2 hijacks host cellular machineries on a system-wide scale so that potential host-directed therapies can be developed. In situ proteome-wide abundance and thermal stability measurements using thermal proteome profiling (TPP) can inform on global changes in pro  ...[more]

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