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From birth to bite: the evolutionary ecology of India's medically most important snake venoms

ABSTRACT: Venoms of N. naja and D. russelii individuals of various developmental stages, including neonates (<30 days), juveniles (between 1 to 12 months), and mature individuals (>36 months), were sampled with permission from the state forest department of Karnataka. 226 individuals and 9 clutches were examined, including periodic venom collection (every three months) from the same N. naja and D. russelii juvenile individuals to track ontogenetic changes across time. Freshly collected venoms were flash-frozen in liquid nitrogen, lyophilised and stored at -80° C. Venoms were fractionated using RP-HPLC and SDS-PAGE and subjected to tandem mass spectrometry for toxin identification. The relative abundance of each toxin family were estimated and compared across different developmental stages.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Daboia Russelii Naja Naja

TISSUE(S): Venom

SUBMITTER: Kartik Sunagar

LAB HEAD: Dr Kartik

PROVIDER: PXD046781 | Pride | 2024-08-10

REPOSITORIES: Pride

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			Action	DRS
	DaRuKA01_Adult_F1.raw	Raw
	DaRuKA01_Adult_F10.raw	Raw
	DaRuKA01_Adult_F11.raw	Raw
	DaRuKA01_Adult_F12.raw	Raw
	DaRuKA01_Adult_F13.raw	Raw

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Publications

From birth to bite: the evolutionary ecology of India's medically most important snake venoms.

Senji Laxme R R RR Khochare Suyog S Bhatia Siddharth S Martin Gerard G Sunagar Kartik K

BMC biology 20240729 1

<h4>Background</h4>Snake venoms can exhibit remarkable inter- and intraspecific variation. While diverse ecological and environmental factors are theorised to explain this variation, only a handful of studies have attempted to unravel their precise roles. This knowledge gap not only impedes our understanding of venom evolution but may also have dire consequences on snakebite treatment. To address this shortcoming, we investigated the evolutionary ecology of venoms of Russell's viper (Daboia russ ...[more]

PMID: 39075553

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