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Metaproteomic portrait of the healthy human gut microbiota

ABSTRACT: Metaproteomic portrait of the healthy human gut microbiota. Re-analysis of existing datasets, selected based on the following inclusion criteria: human cohort including at least 5 healthy (clearly not labeled as diseased) adult (>18 years old) individuals; data derived from LC-MS/MS DDA label-free analysis of fecal samples (with neither subcellular fractionation of microbial cells nor offline fractionation of peptides); availability of raw MS data on public repositories.

INSTRUMENT(S): orbitrap

ORGANISM(S): Human Gut Metagenome

TISSUE(S): Feces

SUBMITTER: Alessandro Tanca

LAB HEAD: Sergio Uzzau

PROVIDER: PXD046818 | Pride | 2024-05-16

REPOSITORIES: Pride

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			Action	DRS
	D01.pdResult	Other
	D01_peptides-annotations_Meta4Ptable.txt	Txt
	D02.pdResult	Other
	D02_peptides-annotations_Meta4Ptable.txt	Txt
	D03.pdResult	Other

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Publications

Metaproteomic portrait of the healthy human gut microbiota.

Tanca Alessandro A Palomba Antonio A Fiorito Giovanni G Abbondio Marcello M Pagnozzi Daniela D Uzzau Sergio S

NPJ biofilms and microbiomes 20240628 1

Gut metaproteomics can provide direct evidence of microbial functions actively expressed in the colonic environments, contributing to clarify the role of the gut microbiota in human physiology. In this study, we re-analyzed 10 fecal metaproteomics datasets of healthy individuals from different continents and countries, with the aim of identifying stable and variable gut microbial functions and defining the contribution of specific bacterial taxa to the main metabolic pathways. The "core" metapro ...[more]

PMID: 38944645

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